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02
2022
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06
What are the classifications of APIs?
Author:
According to the source, it can be divided into chemically synthesized APIs and natural chemical APIs.
(1) Chemical synthesis of APIs
Chemically synthesized APIs can be further divided into inorganic synthetic APIs and organic synthetic APIs. Inorganic synthetic APIs are inorganic compounds, such as aluminum hydroxide used to treat stomach; organic synthetic APIs mainly refer to APIs (aspirin, caffeine, etc.) obtained from organic chemical raw materials through a series of organic chemical reactions.
(2) Natural chemical raw materials
Natural chemical APIs can be divided into two categories: biochemical APIs and phytochemical APIs.
According to different patent stages, APIs can be divided into three categories: bulk APIs, specialty APIs and patented APIs.
(1) Bulk APIs
It generally includes traditional APIs such as anti-infectives, vitamins, amino acids, antipyretics and analgesics, non-steroidal anti-inflammatory drugs, hormones, alkaloids and organic acids. Such APIs generally do not involve patent issues.
main products
Antibiotics: penicillin industrial salt, amoxicillin, ampicillin, 6-APA, 4-AA, cephalosporins, etc.;
Vitamins: vitamin C, folic acid, calcium pantothenate, vitamin E, vitamin A, etc.;
Antipyretic analgesics: aspirin, caffeine, p-aminophenol, paracetamol, ibuprofen, etc.
(2) Featured APIs
Generally, it refers to products whose patents are about to expire or will expire in the near future, mainly including a series of products such as blood pressure lowering, blood lipid lowering and blood sugar lowering.
main products
Lowering blood pressure: valsartan, losartan, candesartan, etc.;
Lowering blood lipids: atorvastatin, rosuvastatin, etc.;
Hypoglycemic: glipizide, gliclazide, etc.;
Anticoagulant: clopidogrel, etc.
(3) Patented APIs
Generally, it refers to innovative drug products cooperated in the CDMO mode.
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